UTROGESTAN / Progesterone / 200mg - Vaginal Soft Gel Capsule 1's

Nationwide (Philippines)

The usual daily dosage is 200 mg of progesterone (i.e. one 200 mg capsule or two 100 mg capsules taken in two doses, one in the morning and one in the evening), to be inserted deep into the vagina, with or without the help of an applicator. This dosage may be increased depending on the individual patient response.

In the case of partial luteal phase defect (dysovulation, irregular menstrual cycles): the daily dose is 200 mg progesterone, administered over 10 days per menstrual cycle, usually from cycle days 17 to 26.

In the case of infertility associated with total luteal phase defect (oocyte donation): the initial progesterone dose is 100 mg, administered on days 13 and 14 of the transfer cycle, followed by 100 mg of progesterone given in the morning and evening of cycle days 15 to 25. From day 26 onwards, in the event of conception, dosage is increased in weekly increments of 100 mg progesterone per day, to reach a maximum daily dose of 600 mg progesterone, spread over three doses. This dosage is maintained up until day 60.

In the case of luteal phase supplementation during IVF: treatment is initiated in the evening of the transfer, at a rate of 600 mg progesterone spread over three doses (morning, noon and evening).

In the case of threatened abortion or in the prevention of LPD-related recurrent spontaneous abortions: the usual daily dosage is 200 mg to 400 mg progesterone, spread over two doses, to be taken up until gestation week 12.

In the case of threatened preterm delivery: Active treatment: 200 mg - 300 mg x 2 - 3 times/day in 3 days. Maintain dosage: 100 mg - 200 mg/day till suppression of contraction.

• Progesterone